Sciences News

WSU researchers have lengthened their list of environmental toxicants that can negatively affect as many as three generations of an exposed animal’s offspring.

Writing in the online journal PLOS ONE, scientists led by WSU molecular biologist Michael Skinner document reproductive disease and obesity in the descendants of rats exposed to various plastic compounds (including BPA). In a separate article in the journal Reproductive Toxicology, they report the first observation of cross-generation disease from a widely used hydrocarbon jet fuel mixture the military refers to as JP8.

Both studies are the first of their kind to see obesity stemming from the process of “epigenetic transgenerational inheritance.

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Eight WSU faculty members have been named fellows of the American Association for the Advancement of Science, including six in the College of Arts and Sciences:

• Sue Clark, regents professor of chemistry
• Daryll DeWald, dean of the College of Arts and Sciences
• Herbert Hill Jr., regents professor of chemistry
• Ursula Mazur, professor of chemistry and materials science
• Kenneth Nash, professor of chemistry
• Michael Skinner, professor of biological sciences

Also named a fellow this year is psychology alumnus John Roll, professor of nursing and associate dean for faculty affairs in the WSU College of Nursing.

You may read more details at the WSU News Center.

Michael Skinner

By Eric Sorensen, WSU science writer

Since the 1960s, when the defoliant Agent Orange was widely used in Vietnam, military, industry, and environmental groups have debated the toxicity of one of its ingredients, the chemical dioxin, and how it should be regulated.

But even if all the dioxin were eliminated from the planet, Washington State University researchers say its legacy would live on in the way it turns genes on and off in the descendants of people exposed over the past half century.

Writing in the journal PLoS ONE, biologist Michael Skinner and members of his lab say dioxin administered to pregnant rats resulted in a variety of reproductive problems and disease in subsequent generations. The first generation of rats had prostate disease, polycystic ovarian disease, and fewer ovarian follicles, the structures that contain eggs. To the surprise of Skinner and his colleagues, the third generation had even more dramatic incidences of ovarian disease and, in males, kidney disease.  Continue story →